AdenylateKinase:An Oncodevelopmental Marker in an AnimalModelfor Human ProstaticCancer
نویسنده
چکیده
Data are presented demonstrating that adenylate kinase (AK; EC 2.7.4.3) is an oncodevelopmentalenzyme in the prostate of Copenhagen rats. We selected the Dunning tumor (dorsal rat prostate) as a model system because it most nearly approximatesthe human pathology.Four sublines of the tumor (R3327-H, R3327-AT, MAT Lu, and MAT LyLu)were studied.The tumor sublineswere maintainedas solid tumors in syngeneic rats and as monolayersin tissue culture. AK activity appeared in conjunction with malignant transformation of the dorsal prostate. We also determined the normal developmental enzyme pattern: AK was present in prostatesof newborns, but was undetectable In prostates of adults.However,AK increasedafter castration.Therefore, we propose AK as a potential oncofetal tumor marker in prostatic cancer.
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